Spinal NMDA NR1 subunit expression following transient TNBS colitis
نویسندگان
چکیده
منابع مشابه
Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats
BACKGROUND N-methyl-D-aspartic acid (NMDA) spinal cord receptors play an important role in the development of hyperalgesia following inflammation. It is unclear, however, if changes in NMDA subunit receptor gene expression in the colonic myenteric plexus are associated with colonic inflammation. We investigated regulation of NMDA-NR1 receptor gene expression in TNBS induced colitis in rats. Mal...
متن کاملAntidepressant Interactions with the NMDA NR1-1b Subunit
The targets for tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and selective norepinephrine reuptake inhibitors (SNRIs) are known to be the serotonin and norepinephrine transport (reuptake) proteins which are embedded in presynaptic nerve terminals and function to bring these neurotransmitters from the synaptic cleft back into the presynaptic neuron. Using a ...
متن کاملMolecular biology of the apteronotus NMDA receptor NR1 subunit.
The complete sequences and expression patterns of the NR1 (aptNR1) subunit of the N-methyl-d-aspartate (NMDA) receptor and its alternative splice isoforms have been determined for the weakly electric fish Apteronotus leptorhynchus. The deduced amino acid sequence of aptNR1 is approximately 88 % identical to the NR1 sequences of other vertebrate. Two of the three alternative splice cassettes pre...
متن کاملExpression of NR1 subunit of NMDA receptor and PSD-93/95 in rat hippocampus affected by NR1/NR2 antisense oligodeoxynucleotide
Background Abnormal protein expression of N-methyl-D-aspartate (NMDA) receptors essential subunits (NR1, NR2) and of associated post-synaptic density proteins (PSD-95, PSD-93) were observed in schizophrenic patients (postmortem studies) [1,2]. NMDA receptors containing NNR2A/B subunit associate in vivo at synapses with PSD-93 and PSD-95 [3]. In the present study, we have silenced the expression...
متن کاملAlterations of NMDA receptor subunits NR1, NR2A and NR2B mRNA expression and their relationship to apoptosis following transient forebrain ischemia.
Glutamate excitotoxicity mediated by NMDA receptor activation plays a key role in many aspects of ischemic brain injury, but the expression of NMDA receptor subunits NR1, NR2A and NR2B mRNA and their relationship to apoptosis is still unclear. In this study, we applied in situ hybridization and TUNEL staining to investigate the expression of NMDA receptor subunit mRNA and apoptosis in hippocamp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Brain Research
سال: 2009
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2009.04.038